Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trifluoroacetic acid methylene chloride → 2-Chloro-3-fluoropyridin-4-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trifluoroacetic acid methylene chloride | HCID 21863450 | — |
| 반응물 | Tert-butyl (2-chloro-3-fluoropyridin-4-yl)carbamate | HCID 86723306 | — |
| 생성물 | 2-Chloro-3-fluoropyridin-4-amine | HCID 60150289 | — |
반응 단계
A solution of tert-butyl N-(2-chloro-3-fluoro-4-pyridyl)carbamate (20.2 mmol) in 1:2 TFA/DCM (45 mL) was stirred at room temperature for 6 h. The reaction mixture was concentrated and the residue was purified by flash column chromatography (SiO2, 100:0 to 90:10 DCM/7N NH3 in MeOH) to yield the desired product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09440929B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-cf5a7b68adc8497681ed4d00ea860847 |
| 출처 메모 | uspto-grants-2016_09 |