Water → HCID 66958805, compound

Participants

Reaction Steps

tert-Butyl 2-aminoethylcarbamate (54.1 g, 338 mmol) was added to a stirred solution of 7-benzyloxy-4-chloro-3-nitroquinoline (88.6 g, 282 mmol) and triethylamine (58.9 mL, 422 mmol) in DMF (800 mL) at room temperature. The reaction mixture was stirred for 4 hours, then was poured onto stirred hot water in a beaker to precipitate a yellow solid that was isolated by filtration and dried under vacuum at 65° C. to yield 123.7 g of tert-butyl 2-{[7-(benzyloxy)-3-nitroquinolin-4-yl]amino}ethylcarbamate.

Provenance & Evidence