反应详情

To 4-(2-acetoxy-ethyl)-4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-piperidine-1-carboxylic acid tert-butyl ester (Ex. 1b, 420 mg) was added 5 mL of 4 N HCl in dioxane. The mixture was stirred for 3 h and then concentrated under reduced pressure. The resulting solid was washed with Ethyl acetate/hexanes (1:3, 20 mL) and dried under high vacuum to afford acetic acid 2-[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-piperidin-4-yl]-ethyl ester hydrochloride as a white solid (370 mg, 100%). ESI/CI-MS m/z 408 ([M+H]+).

1. concentrationconcentrated under reduced pressure
2. washThe resulting solid was washed with Ethyl acetate/hexanes (1:3, 20 mL)
3. customdried under high vacuum