反应详情

Under a nitrogen atmosphere, 8.5 g (21.10-3 mol) of 4-cyanophenyl 2,3,4-tri-O-acetyl-1,5-dithio-β-D-xylopyranoside (Example 1a) are suspended in 100 ml of methanol, and 2 ml of sodium methylate (8% w/v of Na in methanol) are then added. The reaction medium is stirred at room temperature until the starting material has completely dissolved (2 hours) and is then neutralized by the addition of Amberlite® IR 120 H+ resin. The methanol is evaporated off under reduced pressure; the crude product obtained is recrystallized from an ethanol/water mixture (65/25 v/v) to give 5.3 g (yield: 89.7%) of the expected product.

1. dissolutionhas completely dissolved (2 hours)
2. additionis then neutralized by the addition of Amberlite® IR 120 H+ resin
3. customThe methanol is evaporated off under reduced pressure
4. customthe crude product obtained
5. customis recrystallized from an ethanol/water mixture (65/25 v/v)