Acetic Acid → HCID 59848712, compound

Participants

Reaction Conditions

Reaction Steps

1-Isopropylpiperazine (4.4 ml, 30.6 mmol) was added to a solution of 3-(dimethylamino)acrolein (2.82 g, 25.5 mmol) in ethanol (100 ml), followed by formaldehyde (37% solution in water, 2.3 ml, 30.6 mmol) and acetic acid (100 μl). The mixture was stirred at 50° C. for 3.5 hours, then room temperature for 15 hours. The solution was concentrated in vacuo, re-dissolved in ethanol (25 ml) and then formaldehyde (2.3 ml) and acetic acid (100 μl) were added. The mixture was stirred at 60° C. for 4 hours then concentrated in vacuo to yield the title compound as a pale yellow oil (6.10 g, 90%).

Provenance & Evidence