Benzenemethanamine, 3,4-dichloro- → 4-((3,4-Dichlorobenzyl)amino)benzo[d][1,2,3]triazine-8-carboxamide

HRID 59961Notes

Reaction equation

HRID 59961 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][NH2:10])[CH:5]=[CH:6][C:7]=1[Cl:8].O[C:12]1[C:13]2[CH:21]=[CH:20][CH:19]=[C:18]([C:22]([NH2:24])=[O:23])[C:14]=2[N:15]=[N:16][N:17]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:5]=[CH:6][C:7]=1[Cl:8])[CH2:9][NH:10][C:12]1[C:13]2[CH:21]=[CH:20][CH:19]=[C:18]([C:22]([NH2:24])=[O:23])[C:14]=2[N:15]=[N:16][N:17]=1

Participants

3

Reactant 2

HCID 1608Benzenemethanamine, 3,4-dichloro-HCID 1785136134-oxo-1H-1,2,3-benzotriazine-8-carboxamide

Product 1

HCID 745386894-((3,4-Dichlorobenzyl)amino)benzo[d][1,2,3]triazine-8-carboxamide

Procedure

Compound 2 was prepared following general synthetic scheme 7 wherein (3,4-dichlorophenyl)methanamine was reacted with 4-hydroxybenzo[d][1,2,3]-triazine-8-carboxamide to give the title compound. LC-MS [350 (M+1)], 1H NMR (400 MHz, DMSO-d6): δ 9.37 (s, 1H), 9.31 (t, 1H), 8.54 (d, 1H), 8.49 (d, 1H), 8.05 (s, 1H), 8.00 (t, 1H), 7.70 (s, 1H), 7.60 (d, 1H), 7.40 (d, 1H), 4.90 (d, 1H).

Workup

  1. customCompound 2 was prepared

Sources & evidence

ORD record
ord-03bfa14da0a648559a9d736cfbfbcce9
Source dataset
uspto-grants-2016_09
Patent number
US09440968B2

Reaction notes

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