Trifluoroacetic acid → HCID 59027841, compound

Participants

Reaction Steps

5 ml of trifluoroacetic acid are added to a solution consisting of 2.8 g (9.3 mmol) of tert-butoxy[2-(2-trimethylsilanylethyl)thiophen-3-yl]carbamate (IX-1) in 50 ml of dichloromethane. The reaction solution is stirred at room temperature for 3 h and then concentrated under reduced pressure. Column chromatography (gradiant cyclohexane/ethyl acetate 4:1 to 1:1) gives 1.2 g (65% of theory) of 2-(2-trimethylsilanylethyl)thiophen-3-ylamine [log P (pH 2.3)=1.78].

Provenance & Evidence