3-Fluorobenzylamine → HCID 76072947, compound

HRID 59968Notes

Reaction equation

HRID 59968 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH2:8][NH2:9])[CH:5]=[CH:6][CH:7]=1.O[C:11]1[C:12]2[CH:20]=[CH:19][CH:18]=[C:17]([C:21]([NH2:23])=[O:22])[C:13]=2[N:14]=[N:15][N:16]=1>>[F:1][C:2]1[CH:3]=[C:4]([CH:5]=[CH:6][CH:7]=1)[CH2:8][NH:9][C:11]1[C:12]2[CH:20]=[CH:19][CH:18]=[C:17]([C:21]([NH2:23])=[O:22])[C:13]=2[N:14]=[N:15][N:16]=1

Participants

3

Reactant 2

HCID 668533-FluorobenzylamineHCID 1785136134-oxo-1H-1,2,3-benzotriazine-8-carboxamide

Product 1

HCID 76072947HCID 76072947, compound

Procedure

Compound 9 was prepared following general synthetic scheme 7 wherein (3-fluorophenyl)methanamine was reacted with 4-hydroxybenzo[d][1,2,3]-triazine-8-carboxamide to give the title compound. LC-MS [298 (M+1)], 1H NMR (400 MHz, DMSO-d6): 9.39 (s, 1H), 9.32 (s, 1H), 8.55-8.50 (m, 2H), 8.05 (s, 1H), 7.99 (t, 1H), 7.41-7.35 (m, 1H), 7.26-7.23 (m, 2H), 7.11-7.09 (m, 1H), 4.93 (d, 2H).

Workup

  1. customCompound 9 was prepared

Sources & evidence

ORD record
ord-5a6157637ea04ff388b5b7f302663036
Source dataset
uspto-grants-2016_09
Patent number
US09440968B2

Reaction notes

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