1-(1-Benzyl-4-methyl-piperidin-4-yl)-4-methyl-piperazine → 1-Methyl-4-(4-methylpiperidin-4-yl)piperazine

HRID 599730Notes

Reaction equation

HRID 599730 reaction equation
C([N:8]1[CH2:13][CH2:12][C:11]([N:15]2[CH2:20][CH2:19][N:18]([CH3:21])[CH2:17][CH2:16]2)([CH3:14])[CH2:10][CH2:9]1)C1C=CC=CC=1.[H][H]>CO.[Pd]>[CH3:21][N:18]1[CH2:19][CH2:20][N:15]([C:11]2([CH3:14])[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[CH2:16][CH2:17]1

Participants

5

Reactant 2

HCID 672729861-(1-Benzyl-4-methyl-piperidin-4-yl)-4-methyl-piperazineHCID 178418361HCID 178418361, compound2×

Product 1

HCID 467382611-Methyl-4-(4-methylpiperidin-4-yl)piperazine

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A suspension of 0.99 g (3.27 mmol) 1-(1-benzyl-4-methyl-piperidin-4-yl)-4-methyl-piperazine and 200 mg 10% Pd/C in 25 mL MeOH was hydrogenated at 50° C. and 50 psi hydrogen pressure for 2 h. To complete the reaction a further 200 mg catalyst were added and the reaction mixture was hydrogenated for a further 22 h at 60° C. and 50 psi hydrogen pressure. The catalyst was filtered off and the filtrate evaporated to dryness. The product was reacted further without purification.

Workup

  1. customwas hydrogenated at 50° C.
  2. additionwere added
  3. filtrationThe catalyst was filtered off
  4. customthe filtrate evaporated to dryness
  5. customThe product was reacted further without purification

Sources & evidence

ORD record
ord-2e2719b399884ca1b6428ee2cb219ac4
Source dataset
uspto-grants-2011_03
Patent number
US07897603B2

Reaction notes

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