HCID 16124417, compound → HCID 16124319, compound

Participants

Reaction Steps

A solution of 55 mg (0.08 mmol) (R)-1-(6-tert-butoxycarbonylamino-hexylcarbamoyl)-2-(4-hydroxy-3,5-dimethyl-phenyl)-ethyl 4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carboxylate (Example 1.8) in 1 mL of 1M HCl was stirred overnight at RT. The reaction solution was lyophilised and the residue was purified by HPLC. The fractions containing the product were combined and again lyophilised.

Provenance & Evidence