反应详情

Prepared analogously to Example 3c from 80 mg (0.12 mmol) (R)-2-(1′-carboxymethyl-4,4′-bipiperidinyl-1-yl)-1-(4-hydroxy-3,5-dimethyl-benzyl)-2-oxo-ethyl 4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carboxylate and 33 mg (0.23 mmol) 1-(2-hydroxyethyl)-piperidin-2-one. After the elimination of the desiccant and solvent the residue was taken up in DCM and again purified by chromatography (silica gel, DCM/EtOH/NH3 95:5:0.5). The fractions containing the product were combined, concentrated by evaporation i.vac., triturated with DIPE, suction filtered and dried.

1. customagain purified by chromatography (silica gel, DCM/EtOH/NH3 95:5:0.5)
2. additionThe fractions containing the product
3. concentrationconcentrated by evaporation i.vac
4. custom, triturated with DIPE, suction
5. filtrationfiltered
6. customdried