HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-butyl 3-amino-4-(3-chloro-4-fluorophenyl)piperidine-1-carboxylate → 4-[4-(3-Chloro-4-fluoro-phenyl)-piperidin-3-ylamino]-pyrido[3,2-d]pyrimidine-8-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-butyl 3-amino-4-(3-chloro-4-fluorophenyl)piperidine-1-carboxylate | HCID 90190430 | — |
| Reactant | 4-oxo-1H-pyrido[3,2-d]pyrimidine-8-carboxamide | HCID 178513684 | — |
| Product | 4-[4-(3-Chloro-4-fluoro-phenyl)-piperidin-3-ylamino]-pyrido[3,2-d]pyrimidine-8-carboxamide | HCID 90193885 | — |
Reaction Steps
Compound 23 was prepared following general synthesis scheme 9 wherein 4-hydroxy-pyrido[3,2-d]pyrimidine-8-carboxylic acid amide was reacted with tert-butyl 3-amino-4-(3-chloro-4-fluoro-phenyl)piperidine-1-carboxylate to give the title compound. LC-MS [401 (M+H)].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09440968B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-f082b38a76974ce3a5f4fd6cc5070b66 |
| Source note | uspto-grants-2016_09 |