1,1,1,3,3,3-Hexafluoro-2-{4-[(2,2,2-trifluoroethyl)amino]phenyl}propan-2-ol → HCID 11713676, compound

HRID 599810Notes

Reaction equation

HRID 599810 reaction equation
[F:1][C:2]([F:22])([F:21])[C:3]([C:9]1[CH:14]=[CH:13][C:12]([NH:15][CH2:16][C:17]([F:20])([F:19])[F:18])=[CH:11][CH:10]=1)([OH:8])[C:4]([F:7])([F:6])[F:5].Cl[CH2:24][C:25]1[N:26]=[C:27]([C:31]2[CH:36]=[CH:35][CH:34]=[C:33]([Cl:37])[CH:32]=2)[O:28][C:29]=1[CH3:30]>>[Cl:37][C:33]1[CH:32]=[C:31]([C:27]2[O:28][C:29]([CH3:30])=[C:25]([CH2:24][N:15]([CH2:16][C:17]([F:19])([F:18])[F:20])[C:12]3[CH:11]=[CH:10][C:9]([C:3]([OH:8])([C:4]([F:7])([F:6])[F:5])[C:2]([F:21])([F:22])[F:1])=[CH:14][CH:13]=3)[N:26]=2)[CH:36]=[CH:35][CH:34]=1

Participants

3

Reactant 2

HCID 4479111,1,1,3,3,3-Hexafluoro-2-{4-[(2,2,2-trifluoroethyl)amino]phenyl}propan-2-olHCID 121580744-(Chloromethyl)-2-(3-chlorophenyl)-5-methyloxazole

Product 1

HCID 11713676HCID 11713676, compound

Procedure

In analogy to example 22.2, from 1,1,1,3,3,3-hexafluoro-2-[4-(2,2,2-trifluoro-ethylamino)-phenyl]-propan-2-ol and 4-chloromethyl-5-methyl-2-(3-chloro-phenyl)-oxazole was prepared 2-{4-[[2-(3-chloro-phenyl)-5-methyl-oxazol-4-ylmethyl]-(2,2,2-trifluoro-ethyl-amino]-phenyl}-1,1,1,3,3,3-hexafluoro-propan-2-ol, yellow solid, MS: 547 (MH+, 1Cl).

Sources & evidence

ORD record
ord-c92f949d77a64b23b9ead72d57af80c0
Source dataset
uspto-grants-2011_03
Patent number
US07897815B2

Reaction notes

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