Benzylamine → HCID 53325849, compound

Participants

Reaction Steps

The title compound (1.19 g) was prepared from 1.55 g of 4-oxo-piperidine-1-carboxylic acid tert-butyl ester, 850 μL of benzylamine, and 1.43 g of 1-chloro-4-(2-nitro-vinyl)-benzene, using a 1:1 mixture of EtOH/toluene as the solvent. MS (ESI): exact mass calculated for C20H20Cl2N2, 322.12; m/z found, 323.2 [M+H]+, 325.2 [M+H]+. 1H NMR (400 MHz, CD3OD): 7.37-7.26 (m, 7H), 7.18-7.16 (m, 3H), 5.15 (s, 2H), 4.35 (s, 2H), 3.50 (t, J=6.3 Hz, 2H), 2.87 (t, J=6.3 Hz, 2H).

Provenance & Evidence