HCID 818880, compound → HCID 59752569, compound

HRID 599893Notes

Reaction equation

HRID 599893 reaction equation
C(OC([N:8]1[CH2:14][CH2:13][C:12]2[C:15]([C:25]3[S:26][C:27]([Cl:30])=[CH:28][CH:29]=3)=[CH:16][N:17]([CH2:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[C:11]=2[CH2:10][CH2:9]1)=O)(C)(C)C.ClC1SC(C=C[N+]([O-])=O)=CC=1>C(N)C1C=CC=CC=1>[CH2:18]([N:17]1[C:11]2[CH2:10][CH2:9][NH:8][CH2:14][CH2:13][C:12]=2[C:15]([C:25]2[S:26][C:27]([Cl:30])=[CH:28][CH:29]=2)=[CH:16]1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

4

Reactant 2

HCID 818880HCID 818880, compoundHCID 67269058HCID 67269058, compound

Product 1

HCID 59752569HCID 59752569, compound

Reagents, catalysts & solvents 1

HCID 7504BenzylamineSolvent

Procedure

1-Benzyl-3-(5-chloro-thiophen-2-yl)-4,5,7,8-tetrahydro-1H-pyrrolo[2,3-d]azepine-6-carboxylic acid tert-butyl ester. The desired compound (124.5 mg) was prepared from the compound of Example 59, Step B (0.55 g), 280 μL of benzylamine, and 0.49 g of 2-chloro-5-(2-nitro-vinyl)-thiophene as in Example 1, Step A. MS (ESI): exact mass calculated for C24H27ClN2O2S, 442.15. found, m/z 443.2 [M+H]+.

Sources & evidence

ORD record
ord-b596f6447cf943ed9a1b2731072ee329
Source dataset
uspto-grants-2011_03
Patent number
US07897771B2

Reaction notes

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