Phenylboronic Acid → 2-(3-Chloro-phenyl)-3-phenyl-2,4,5,6,7,8-hexahydro-1,2,6-triaza-azulene

HRID 599995Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 599995
C(OC([N:8]1[CH2:17][CH2:16][C:15]2[C:11](=[C:12]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[N:13]([C:18]3[CH:23]=[CH:22][CH:21]=[C:20]([Cl:24])[CH:19]=3)[N:14]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.C(OC(N1CCC2C(=C(OS(C(F)(F)F)(=O)=O)N(C3C=CC=C(Cl)C=3)N=2)CC1)=O)(C)(C)C.ClC1C=C(NN)C=CC=1.C1(B(O)O)C=CC=CC=1>>[Cl:24][C:20]1[CH:19]=[C:18]([N:13]2[C:12]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)=[C:11]3[C:15]([CH2:16][CH2:17][NH:8][CH2:9][CH2:10]3)=[N:14]2)[CH:23]=[CH:22][CH:21]=1

Komponenten

5

Edukt 4

HCID 66827Phenylboronic AcidHCID 75332(3-Chlorophenyl)hydrazineHCID 67269650HCID 67269650, VerbindungHCID 865983822-(3-chloro-phenyl)-3-trifluoromethanesulfonyloxy-4,5,7,8-tetrahydro-2H-1,2,6-triaza-azulene-6-carboxylic acid tert-butyl ester

Produkt 1

HCID 248716162-(3-Chloro-phenyl)-3-phenyl-2,4,5,6,7,8-hexahydro-1,2,6-triaza-azulene

Versuchsvorschrift

2-(3-Chloro-phenyl)-3-phenyl-4,5,7,8-tetrahydro-2H-1,2,6-triaza-azulene-6-carboxylic acid tert-butyl ester. The desired compound (53.9 mg) was prepared from 142.7 mg of 2-(3-chloro-phenyl)-3-trifluoromethanesulfonyloxy-4,5,7,8-tetrahydro-2H-1,2,6-triaza-azulene-6-carboxylic acid tert-butyl ester (made as in Example 176, Steps A and B) replacing phenylhydrazine with (3-chloro-phenyl)-hydrazine, as described in Example 43, Step D, using 102.1 mg of phenylboronic acid. MS (ESI): exact mass calculated for C24H26ClN3O2, 423.17. found, m/z 424.1 [M+H]+.

Quellen und Nachweise

ORD-Eintrag
ord-9c0dbabdeef44c6889e799f7165b9240
Quelldatensatz
uspto-grants-2011_03
Patentnummer
US07897771B2

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