HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-(4-Fluorophenyl)-2-propenoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Malonic Acid | HCID 867 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 4-Fluorobenzaldehyde | HCID 68023 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 3-(4-Fluorophenyl)-2-propenoic acid | HCID 98070 | — |
Reaction Steps
A mixture of 0.1 mol 4-fluorobenzaldehyde, 0.15 mol malonic acid, and 0.1 ml piperidine in 30 ml pyridine is boiled for 10 hours, cooled, and treated with 150 ml HCl having a 10% concentration. The precipitate is filtered and crystallized with ethanol. The yield of 4-fluorocinnamic acid is 68% and the melting point is 211° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07901605B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-51b2e12a00934ae2bc6646559ac01ea3 |
| Source note | uspto-grants-2011_03 |