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HRID600187

反应详情

EQUATION

反应方程式

HRID 600187 的结构方程式

REACTANTS

反应物

1
结构：COC(=O)[C@H]1O[C@@H](Oc2ccc([C@@H]3[C@@H](CC[C@H](O)c4ccc(F)cc4)C(=O)N3c3ccc(C#C[Si](C)(C)C)cc3)cc2)[C@H](O)[C@@H](O)[C@@H]1O
HCID86601873

未命名化合物

PRODUCTS

生成物

1
结构：C#Cc1ccc(N2C(=O)[C@H](CC[C@H](O)c3ccc(F)cc3)[C@H]2c2ccc(O[C@@H]3O[C@H](C(=O)O)[C@@H](O)[C@H](O)[C@H]3O)cc2)cc1
HCID86601872

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCN(CC)CC.CO.O
溶剂HCID23434731

未命名化合物

PROCEDURE

实验过程

A solution of 8a in methanol/water/triethylamine (0.25 mL:1.10 mL:0.40 mL) was stirred at room temperature for approximately 6 h. The volatiles were evaporated in vacuo and the crude residue purified by preparative reversed phase high performance liquid chromatography on YMC Pack Pro C18 phase (gradient elution; 10-65% acetonitrile/water as eluent, 0.1% TFA modifier) to give the title compound (8b); m/z (ES) 574 (M-OH)+, 398; HRMS (ES) m/z calc'd for C32H31FNO9 (MH+) 592.1983, found 592.1985.

WORKUP

后处理

  1. customThe volatiles were evaporated in vacuo
  2. customthe crude residue purified by preparative reversed phase high performance liquid chromatography on YMC Pack Pro C18 phase (gradient elution; 10-65% acetonitrile/water as eluent, 0.1% TFA modifier)