Acetic Acid → {4-[2-(4-Benzyloxy-phenyl)-ethyl]-2-methyl-4,5-dihydro-oxazol-4-yl}-methanol

참여 물질

역할	이름	HCID	투입량
반응물	Acetic Acid	HCID 176	—
반응물	2-Amino-2-[2-(4-benzyloxy-phenyl)-ethyl]-propane-1,3-diol	HCID 21849131	—
반응물	Triethylorthoaceate	HCID 21875354	—
용매	Acetonitrile	HCID 6342	—
생성물	{4-[2-(4-Benzyloxy-phenyl)-ethyl]-2-methyl-4,5-dihydro-oxazol-4-yl}-methanol	HCID 67054626	—

반응 조건

온도	80 °C

반응 단계

To a solution of 2-amino-2-[2-(4-benzyloxy-phenyl)-ethyl]-propane-1,3-diol (31.1 g, 0.10 mol) in acetonitrile (2.38 l) is added triethylortho acetate (17.1 ml, 0.12 mol, 1.2 eq) and acetic acid (5.48 ml, 0.11 mol, 1.1 eq), the reaction mixture is then stirred at 80° C. for 5 hours. The reaction mixture is then concentrated under vacuum, {4-[2-(4-benzyloxy-phenyl)-ethyl]-2-methyl-4,5-dihydro-oxazol-4-yl}-methanol is isolated after crystallization with ethyl acetate.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07902175B2
출처 데이터셋	uspto-grants-2011_03
ORD ID	ord-f9b9f2e5d209449da4f98e290653ee7a
출처 메모	uspto-grants-2011_03