Water → HCID 67269311, compound

Participants

Reaction Steps

A mixture of 10 mg (0.04 mmol) 2-(4-cyclopentyl-piperazin-1-yl)-pyrimidin-4-ylamine, 10.8 mg (0.082 mmol) cyclopentylcarbonyl chloride and 13.5 mg (0.12 mmol) potassium t-butoxide in 0.7 mL THF was shaken at room temperature for 16 h. The mixture was treated with water and methanol and subjected to preparative HPLC purification on reversed phase eluting with a gradient of acetonitrile/water (0.05% triethylamine). The combined product fractions were evaporated to dryness to yield 3 mg (21%) of the title compound as white solid. MS (m/e): 344.1 (MH+).

Provenance & Evidence