Morpholine → (6-Morpholin-4-yl-5,6,7,8-tetrahydro-naphthalen-2-yl)-(2-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone

Participants

Reaction Steps

(6-Morpholin-4-yl-5,6,7,8-tetrahydro-naphthalen-2-yl)-(2-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone is prepared from 4-(6-bromo-1,2,3,4-tetrahydro-naphthalen-2-yl)-morpholine and (S)-(+)-1-(2-pyrrolidinylmethyl)-pyrrolidine in a manner substantially analogous to Procedure A. (See herein Example 1). Starting material, 4-(6-bromo-1,2,3,4-tetrahydro-naphthalen-2-yl)-morpholine, was prepared from 6-bromo-2-tetralone and morpholine in a manner substantially analogous to Preparation 1. Mass spectrum (APCI): 389 (M++1).

Provenance & Evidence