HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine → [6-(4-Methyl-piperazin-1-yl)-5,6,7,8-tetrahydro-naphthalen-2-yl]-(2-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine | HCID 853151 | — |
| Reactant | 6-(4-Methyl-piperazin-1-yl)-5,6,7,8-tetrahydro-naphthalene-2-carboxylic acid dihydrochloride | HCID 67272971 | — |
| Product | [6-(4-Methyl-piperazin-1-yl)-5,6,7,8-tetrahydro-naphthalen-2-yl]-(2-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone | HCID 67273459 | — |
Reaction Steps
[6-(4-methyl-piperazin-1-yl)-5,6,7,8-tetrahydro-naphthalen-2-yl]-(2-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone is prepared from 6-(4-methyl-piperazin-1-yl)-5,6,7,8-tetrahydro-naphthalene-2-carboxylic acid dihydrochloride and (R)-(+)-1-(2-pyrrolidinylmethyl)-pyrrolidine in a manner substantially analogous to Procedure C (See herein Example 13). Observed mass 411 (M++1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07902191B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-31d1d47127ad4b4b8ce2e652ceb3582b |
| Source note | uspto-grants-2011_03 |