2-Bromo-1-(4-fluorophenyl)ethan-1-one → HCID 57433608, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-bromo-1-(4-fluorophenyl)-ethanone (CAS# 403-29-2, I) (60 g, 0.376 mol) in anhydrous tetrahydrofuran (THF) solution (200 ml) was added over 20 minutes a solution of 2-amino-oxazole (A) (16 g, 0.19 mol) in anhydrous acetonitrile at room temperature. The mixture was stirred for 24 hours before cooling to 0° C. The precipitate was collected by filtration and washed with cold acetonitrile (3×30 mL) and dried in a vacuum oven to yield light yellow crystals of 1-(4-fluorophenyl)-2-(2-imino-1,3-oxazol-3(2H)-yl)ethanone hydrobromide (B) (42.0 g, 77%). MS (ES+) 203 (M+1).

Provenance & Evidence