Methanol → HCID 58541669, compound

Participants

Reaction Steps

To a solution of 6-(4-fluorophenyl)-5-[2-(methylsulfanyl)pyrimidin-4-yl]imidazo[2,1-b][1,3]oxazole (E) (2.0 g, 6.13 mmol) in methanol (250 mL) is slowly added Oxone™ (potassium monopersulfate) (11.3 g, 18.4 mmol) in water (50 mL). The mixture is stirred at room temperature for 24 hours. The solvent is removed in vacuo and the residue dissolved in dichloromethane, washed with water, and dried over anhydrous sodium sulfate. The solids are removed by filtration and the solvent removed in vacuo. The residue is purified by silica gel column chromatography to provide 6-(4-fluorophenyl)-5-[2-(methylsulfonyl)pyrimidin-4-yl]imidazo[2,1-b][1,3]oxazole (F) (Compound XI, Table 1)) as a white solid (1.8 g, 82%).

Provenance & Evidence