反应详情

To a solution of acetic acid 4-nitro-pyridin-2-ylmethyl ester (16)(0.49 g, 2.5 mmol) in methanol (5 mL), was added a solution of sodium hydroxide (2N, 1.6 mL) and the reaction was stirred for 30 minutes and then concentrated in vacuo. The residue was diluted with water (10 mL) and extracted with ethyl acetate (2×10 mL). The combined extracts were washed with brine (10 mL) and concentrated in vacuo to afford a crude oil which solidified upon standing. Single peak in LC-MS analysis, (0.13 g 33%); m/z (LC-MS, ESP), RT=2.67 mins, (M+H) 155.

1. concentrationconcentrated in vacuo
2. additionThe residue was diluted with water (10 mL)
3. extractionextracted with ethyl acetate (2×10 mL)
4. washThe combined extracts were washed with brine (10 mL)
5. concentrationconcentrated in vacuo
6. customto afford a crude oil which