Ammonia → HCID 59856572, compound

HRID 600276Notes

Reaction equation

HRID 600276 reaction equation
C[O:2][C:3](=O)[CH2:4][N:5]1[C:9]([CH3:11])([CH3:10])[C:8](=[O:12])[N:7]([C:13]2[CH:18]=[C:17]([CH2:19][C:20]3[C:29]4[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=4)[C:23](=[O:30])[NH:22][N:21]=3)[CH:16]=[CH:15][C:14]=2[F:31])[C:6]1=[O:32].CO.[NH3:36]>>[F:31][C:14]1[CH:15]=[CH:16][C:17]([CH2:19][C:20]2[C:29]3[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=3)[C:23](=[O:30])[NH:22][N:21]=2)=[CH:18][C:13]=1[N:7]1[C:8](=[O:12])[C:9]([CH3:11])([CH3:10])[N:5]([CH2:4][C:3]([NH2:36])=[O:2])[C:6]1=[O:32]

Participants

4

Reactant 3

HCID 222AmmoniaHCID 887MethanolHCID 59856552HCID 59856552, compound

Product 1

HCID 59856572HCID 59856572, compound

Conditions

Temperature
60 °C

Procedure

{3-[2-Fluoro-5-(4-oxo-3,4-dihydro-phthalazin-1-ylmethyl)-phenyl]-5,5-dimethyl-2,4-dioxo-imidazolidin-1-yl}-acetic acid methyl ester (0.025 g, 0.055 mmol) was dissolved in solution of 7N ammonia in methanol (3 ml, 21 mmol) and heated in a sealed tube at 60° C. for 18 hours. The resultant solution was concentrated in vacuo and submitted for preparative HPLC purification.

Workup

  1. concentrationThe resultant solution was concentrated in vacuo
  2. customsubmitted for preparative HPLC purification

Sources & evidence

ORD record
ord-7df1523f65b1406e8877dbfba8ea39b4
Source dataset
uspto-grants-2011_03
Patent number
US07902193B2

Reaction notes

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