HCID 57999634, compound → HCID 42641554, compound

Participants

Reaction Conditions

Reaction Steps

A solution of (S)-tert-butyl 2-((S)-2-(biphenyl-4-yl)-1-cyanoethylcarbamoyl)pyrrolidine-1-carboxylate (178 mg) in formic acid (5 mL) was stirred and heated at 50° C. for 10 min. The solvent was evaporated. The crude material was dissolved in methanol (2 mL) and loaded on to a 10 g SCX cartridge. The impurities were washed through with methanol (20 mL) and discarded. The product was eluted with 0.7 N methanolic ammonia (15 mL) and evaporated in vacuo. The residue was triturated with ethyl acetate (3 mL) and the solid collected, washed with a little ethyl acetate and dried to afford the title compound (92 mg).

Provenance & Evidence