m-Chloroperbenzoic acid → HCID 57999688, compound

Participants

Reaction Steps

3-Chloroperoxybenzoic acid (0.137 g) was added to a solution of (S)-tert-butyl 2-((S)-1-cyano-2-(4′-cyano-3′-(methylthio)biphenyl-4-yl)ethylcarbamoyl)piperidine-1-carboxylate (0.140 g) in DCM (20 mL) at 0° C. and the mixture was stirred for 2 h then allowed to warm to RT. The mixture was washed with saturated sodium bicarbonate solution, sodium metabisulfite solution, water and brine then dried over sodium sulfate and evaporated. Purification by flash silica chromatography eluting with 30-50% ethyl acetate in isohexane afforded a colourless solid (0.08 g).

Provenance & Evidence