Formic Acid → HCID 42642567, compound

Participants

Reaction Conditions

Reaction Steps

A solution of (2S)-tert-butyl 2-((1S)-1-cyano-2-(4′-cyano-3′-(methylsulfinyl)biphenyl-4-yl)ethylcarbamoyl)piperidine-1-carboxylate (0.08 g) in formic acid (2 mL) was stirred and heated at 50° C. for 10 min. The mixture was evaporated and applied to a 10 g SCX column. The column was washed with methanol then eluted with 10% ammonia in methanol. The eluate was evaporated and the residue dissolved in isopropanol and precipitated with diethyl ether. The solid was collected, washed with diethyl ether and dried over magnesium sulfate. Purification by RPHPLC using aqueous 0.1% TFA afforded the major product as a colourless solid (0.027 g).

Provenance & Evidence