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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 600324Generated: October 29, 2026

(2-Hydroxyphenyl)boronic acid → (S)-N-((S)-1-Cyano-2-(6-(2-hydroxyphenyl)pyridin-3-yl)ethyl)piperidine-2-carboxamide

https://huagongshe.com/reaction/600324

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(2-Hydroxyphenyl)boronic acidHCID 2773454—
Reactant(S)-tert-Butyl 2-((S)-2-(6-bromopyridin-3-yl)-1-cyanoethylcarbamoyl)piperidine-1-carboxylateHCID 57999686—
Product(S)-N-((S)-1-Cyano-2-(6-(2-hydroxyphenyl)pyridin-3-yl)ethyl)piperidine-2-carboxamideHCID 136132894—

Reaction Steps

Prepared by a process analogous to that described in Method 2 Example 2 using (S)-tert-butyl 2-((S)-2-(6-bromopyridin-3-yl)-1-cyanoethylcarbamoyl)piperidine-1-carboxylate and 2-hydroxyphenylboronic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07902181B2
Source datasetuspto-grants-2011_03
ORD IDord-ddd18768dbe14f27956dd1e69ff85bf0
Source noteuspto-grants-2011_03