3-(2-Cyanoethylaminocarbonyl)benzeneboronic acid → (S)-N-((S)-1-Cyano-2-(3'-(2-cyanoethylcarbamoyl)biphenyl-4-yl)ethyl)piperidine-2-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	3-(2-Cyanoethylaminocarbonyl)benzeneboronic acid	HCID 3690598	—
Reactant	(S)-tert-Butyl 2-((S)-1-cyano-2-(4-iodophenyl)ethylcarbamoyl)piperidine-1-carboxylate	HCID 57999629	—
Product	(S)-N-((S)-1-Cyano-2-(3'-(2-cyanoethylcarbamoyl)biphenyl-4-yl)ethyl)piperidine-2-carboxamide	HCID 42641214	—

Reaction Steps

Prepared by a process analogous to that described in Method 2 Example 2 using (S)-tert-butyl 2-((S)-1-cyano-2-(4-iodophenyl)ethylcarbamoyl)piperidine-1-carboxylate and 3-(2-cyanoethylcarbamoyl)phenylboronic acid. NMR appeared to show the product was a free base.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07902181B2
Source dataset	uspto-grants-2011_03
ORD ID	ord-d9a1cef1b27f4107977bac98126baed7
Source note	uspto-grants-2011_03