(S)-tert-butyl 2-((S)-1-cyano-2-(4-(3-methyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)phenyl)ethylcarbamoyl)piperidine-1-carboxylate → (S)-N-((S)-1-Cyano-2-(4-(3-methyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)phenyl)ethyl)piperidine-2-carboxamide

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A solution of (S)-tert-butyl 2-((S)-1-cyano-2-(4-(3-methyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)phenyl)ethylcarbamoyl)piperidine-1-carboxylate (87 mg) in formic acid (1 mL) was stirred at 50° C. for 15 min. The solvent was removed in vacuo and the residue was purified by flash silica chromatography eluting with 1:29 ammonia in methanol/DCM to give a white solid, which was triturated with diethyl ether to give the title compound (46 mg) as a white solid.

Provenance & Evidence