HRID600330

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)N1CCCC[C@H]1C(=O)N[C@@H](Cc1ccc(B2OC(C)(C)C(C)(C)O2)cc1)C(N)=O

HCID57999680

未命名化合物

HCID57999690

未命名化合物

PRODUCTS

生成物

结构：COCCn1c(=O)oc2ccc(-c3ccc(C[C@H](NC(=O)[C@@H]4CCCCN4C(=O)OC(C)(C)C)C(N)=O)cc3)cc21

HCID57999678

未命名化合物

PROCEDURE

实验过程

The sub-title compound was prepared by the method of Example 96 step (a) using 5-bromo-3-(2-methoxyethyl)benzo[d]oxazol-2(3H)-one and (S)-tert-butyl 2-((S)-1-amino-1-oxo-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propan-2-ylcarbamoyl)piperidine-1-carboxylate.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-8470495353a9486487d047259653d29c
来源数据集: uspto-grants-2011_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07902181B2
来源说明: uspto-grants-2011_03

反应 SMILES

Br[C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8](=[O:10])[N:7]([CH2:11][CH2:12][O:13][CH3:14])[C:6]=2[CH:15]=1.[NH2:16][C:17](=[O:51])[C@@H:18]([NH:35][C:36]([C@@H:38]1[CH2:43][CH2:42][CH2:41][CH2:40][N:39]1[C:44]([O:46][C:47]([CH3:50])([CH3:49])[CH3:48])=[O:45])=[O:37])[CH2:19][C:20]1[CH:25]=[CH:24][C:23](B2OC(C)(C)C(C)(C)O2)=[CH:22][CH:21]=1>>[NH2:16][C:17](=[O:51])[C@@H:18]([NH:35][C:36]([C@@H:38]1[CH2:43][CH2:42][CH2:41][CH2:40][N:39]1[C:44]([O:46][C:47]([CH3:49])([CH3:48])[CH3:50])=[O:45])=[O:37])[CH2:19][C:20]1[CH:25]=[CH:24][C:23]([C:2]2[CH:3]=[CH:4][C:5]3[O:9][C:8](=[O:10])[N:7]([CH2:11][CH2:12][O:13][CH3:14])[C:6]=3[CH:15]=2)=[CH:22][CH:21]=1