HRID600333

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID14317495

未命名化合物

结构：CC(C)(C)OC(=O)N1CCCC[C@H]1C(=O)N[C@@H](Cc1ccc(B2OC(C)(C)C(C)(C)O2)cc1)C(N)=O

HCID57999680

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)N1CCCC[C@H]1C(=O)N[C@@H](Cc1ccc(-c2ccc3c(c2)sc(=O)n3CCO)cc1)C(N)=O

HCID57999687

未命名化合物

PROCEDURE

实验过程

The subtitle compound was prepared by the method of Example 96 step (a) using (S)-tert-butyl 2-((S)-1-amino-1-oxo-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propan-2-ylcarbamoyl)piperidine-1-carboxylate and 6-bromo-3-(2-hydroxyethyl)benzo[d]thiazol-2(3H)-one.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-9b69352037334c58b9b15ad498166ce7
来源数据集: uspto-grants-2011_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07902181B2
来源说明: uspto-grants-2011_03

反应 SMILES

[NH2:1][C:2](=[O:36])[C@@H:3]([NH:20][C:21]([C@@H:23]1[CH2:28][CH2:27][CH2:26][CH2:25][N:24]1[C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30])=[O:22])[CH2:4][C:5]1[CH:10]=[CH:9][C:8](B2OC(C)(C)C(C)(C)O2)=[CH:7][CH:6]=1.Br[C:38]1[CH:50]=[CH:49][C:41]2[N:42]([CH2:46][CH2:47][OH:48])[C:43](=[O:45])[S:44][C:40]=2[CH:39]=1>>[NH2:1][C:2](=[O:36])[C@@H:3]([NH:20][C:21]([C@@H:23]1[CH2:28][CH2:27][CH2:26][CH2:25][N:24]1[C:29]([O:31][C:32]([CH3:33])([CH3:34])[CH3:35])=[O:30])=[O:22])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([C:38]2[CH:50]=[CH:49][C:41]3[N:42]([CH2:46][CH2:47][OH:48])[C:43](=[O:45])[S:44][C:40]=3[CH:39]=2)=[CH:7][CH:6]=1