Sodium Acetate Trihydrate → 1-cyclohexyl-3-[7-(2,2-dimethyl-propionyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-urea

Participants

Reaction Steps

A solution of 1-cyclohexyl-3-[7-(2,2-dimethyl-propionyl)-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-urea (0.102 g, 0.215 mmol) in 2 mL of dichloromethane and 2 mL of trifluoroacetic acid was stirred for 1 h, then concentrated, chasing twice with toluene. The residue was dissolved in 2 mL of ethanol and treated with sodium acetate trihydrate (0.293 g, 2.15 mmol). The mixture was stirred for 16 h, then concentrated to a residue. Column chromatography (50→80% EtOAc/hexanes) afforded 0.050 g (68%) of 1-cyclohexyl-3-[7-(2,2-dimethyl-propionyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-urea as a white solid.

Provenance & Evidence