反应详情

温度

110 °C

General procedure for displacement reactions of 6-chloropurinones with aliphatic amines. To 10 mg (0.022 mmol) of 6-chloro-2-(6-fluoro-1H-benzo[d]imidazol-1-yl)-9-((R)-8-fluorochroman-4-yl)-7H-purin-8(9H)-one was added 0.6 mL of 1-butanol, followed by an aliphatic amine (0.1 mL), and the reaction mixture was stirred at 110° C. for 1-2 h (HPLC monitoring). Upon completion of the reaction, the mixture was left to cool to room temperature, was diluted with acetonitrile and filtered through a Nylon 0.45 μm filter. Preparative HPLC purification afforded, after solvent evaporation and drying, the desired product.

1. customUpon completion of the reaction
2. waitthe mixture was left
3. temperatureto cool to room temperature
4. filtrationfiltered through a Nylon 0.45 μm
5. filtrationfilter
6. customPreparative HPLC purification
7. customafforded
8. customafter solvent evaporation
9. customdrying