反应详情

6-chloropyrimidine-2,4,5-triamine hydrochloride was prepared as described in WO 94/07892. 2,5-Diamino-4,6-dichloropyrimidine (10.8 g, 60.3 mmol) and concentrated aqueous ammonia (30 mL) were heated together in a sealed tube at 105° C. for 18 h, then cooled to room temperature. 2.34 g NaOH in water (10 mL) was added and the excess ammonia stripped out by concentrating to a low volume. Dilute HCl 2N (35 mL) and water (10 mL) were added and heated to dissolve, cooled to crystallize, then filtered to give the desired 6-chloropyrimidine-2,4,5-triamine hydrochloride (87% yield). MS (EI) m/z 160.1 (MH)+.

1. custom6-chloropyrimidine-2,4,5-triamine hydrochloride was prepared
2. concentrationby concentrating to a low volume
3. additionDilute HCl 2N (35 mL) and water (10 mL) were added
4. temperatureheated
5. dissolutionto dissolve
6. temperaturecooled
7. customto crystallize
8. filtrationfiltered