Trimethylsilyl iodide → HCID 178481616, compound

Participants

Reaction Steps

To an oven dried flask under Argon flow was added 3-(6-chloro-9-(trans-4-methoxycyclohexyl)-7-methyl-8-oxo-8,9-dihydro-7H-purin-2-yl)-3H-benzo[d]imidazole-5-carbonitrile (0.55 g, 1.25 mmol) in chloroform, followed by iodotrimethylsilane (0.1 mL, 1.25 mmol, 1 equiv.) The reaction mixture was stirred at room temperature for 4 h. Upon completion (HPLC monitoring), the reaction was slowly quenched with water. The organic layer was separated and the aqueous layer extracted with CHCl3 (15 ml×3) and with EtOAc (15 mL×3). The combined organic layers were dried (MgSO4), and concentrated in vacuo to give a dark solid (66% crude yield). MS (EI) m/z 424 (MH)+.

Provenance & Evidence