HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Pyridin-2-yl-isoxazole-4-carboxylic acid ethyl ester → 3-Pyridin-2-yl-isoxazole-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Pyridin-2-yl-isoxazole-4-carboxylic acid ethyl ester | HCID 66643758 | — |
| Reactant | 5-[3-(4-Chloro-phenyl)-isoxazol-4-ylmethoxy]-pyrazine-2-carboxylic acid methyl ester | HCID 67157839 | — |
| Product | 3-Pyridin-2-yl-isoxazole-4-carboxylic acid | HCID 66643528 | 79% |
Reaction Steps
As described for example 17a, 3-pyridin-2-yl-isoxazole-4-carboxylic acid ethyl ester (9.6 g, 44 mmol), instead of 5-[3-(4-chloro-phenyl)-isoxazol-4-ylmethoxy]-pyrazine-2-carboxylic acid methyl ester, was converted to the title compound (6.5 g, 79%) which was obtained as an off-white solid. MS: m/e=189.3 [M−H]−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07902201B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-1a9257810eb24981a97cdfde4b95ca80 |
| Source note | uspto-grants-2011_03 |