5-[3-(4-Chloro-phenyl)-isoxazol-4-ylmethoxy]-pyrazine-2-carboxylic acid methyl ester → HCID 68446246, compound

HRID 600504Notes

Reaction equation

HRID 600504 reaction equation
C[O:2][C:3]([C:5]1[CH:10]=[N:9][C:8]([O:11][CH2:12][C:13]2[C:14]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=3)=[N:15][O:16][CH:17]=2)=[CH:7][N:6]=1)=[O:4].COC(C1C=NC(OCC2C(C3C=CC(Cl)=CC=3)=NOC=2)=CN=1)=O>>[N:19]1[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=1[C:14]1[C:13]([CH2:12][O:11][C:8]2[N:9]=[CH:10][C:5]([C:3]([OH:4])=[O:2])=[N:6][CH:7]=2)=[CH:17][O:16][N:15]=1

Participants

3

Reactant 2

HCID 671578395-[3-(4-Chloro-phenyl)-isoxazol-4-ylmethoxy]-pyrazine-2-carboxylic acid methyl esterHCID 68445648HCID 68445648, compound

Product 1

HCID 68446246HCID 68446246, compoundYield 71%

Procedure

As described for example 17a, 5-(3-pyridin-2-yl-isoxazol-4-ylmethoxy)-pyrazine-2-carboxylic acid methyl ester (432 mg, 1.4 mmol), instead of 5-[3-(4-chloro-phenyl)-isoxazol-4-ylmethoxy]-pyrazine-2-carboxylic acid methyl ester, was converted to the title compound (285 mg, 71%) which was obtained as a white solid. MS: m/e=297.1 [M−H]−.

Sources & evidence

ORD record
ord-f4a66148bff64455ac20f8a343e8158b
Source dataset
uspto-grants-2011_03
Patent number
US07902201B2

Reaction notes

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