Isopropylamine → HCID 46937847, compound

HRID 600506Notes

Reaction equation

[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[C:11]([CH2:12][O:13][C:14]2[N:15]=[CH:16][C:17]([C:20]([OH:22])=O)=[N:18][CH:19]=2)=[CH:10][O:9][N:8]=1.[CH:23]([NH2:26])([CH3:25])[CH3:24]>>[CH:23]([NH:26][C:20]([C:17]1[CH:16]=[N:15][C:14]([O:13][CH2:12][C:11]2[C:7]([C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=3)=[N:8][O:9][CH:10]=2)=[CH:19][N:18]=1)=[O:22])([CH3:25])[CH3:24]

Participants

Reactant 2

HCID 6363Isopropylamine

HCID 68446246HCID 68446246, compound

Product 1

HCID 46937847HCID 46937847, compoundYield 68%

Procedure

As described for example 19f, 5-(3-pyridin-2-yl-isoxazol-4-ylmethoxy)-pyrazine-2-carboxylic acid (83.6 mg, 2.8 mmol) was converted, using isopropylamine instead of 4-aminotetrahydropyran, to the title compound (SiO2, heptane:ethyl acetate 4:1 to 3:7, 65 mg, 68%) which was obtained as a white solid. MS: m/e=340.2 [M+H]+.

Sources & evidence

ORD record: ord-68b495e69d3b407f8c3f194fd4bb3268
Source dataset: uspto-grants-2011_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07902201B2

Reaction notes

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