Cyclopropylamine → HCID 46937848, compound

HRID 600507Notes

Reaction equation

HRID 600507 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[C:11]([CH2:12][O:13][C:14]2[N:15]=[CH:16][C:17]([C:20]([OH:22])=O)=[N:18][CH:19]=2)=[CH:10][O:9][N:8]=1.[CH:23]1([NH2:26])[CH2:25][CH2:24]1>>[CH:23]1([NH:26][C:20]([C:17]2[CH:16]=[N:15][C:14]([O:13][CH2:12][C:11]3[C:7]([C:2]4[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=4)=[N:8][O:9][CH:10]=3)=[CH:19][N:18]=2)=[O:22])[CH2:25][CH2:24]1

Participants

3

Reactant 2

HCID 69828CyclopropylamineHCID 68446246HCID 68446246, compound

Product 1

HCID 46937848HCID 46937848, compoundYield 81%

Procedure

As described for example 19f, 5-(3-pyridin-2-yl-isoxazol-4-ylmethoxy)-pyrazine-2-carboxylic acid (84.7 mg, 2.8 mmol) was converted, using cyclopropylamine instead of 4-aminotetrahydropyran, to the title compound (SiO2, heptane:ethyl acetate 7:3 to 2:8, 78 mg, 81%) which was obtained as a white solid. MS: m/e=338.3 [M+H]+.

Sources & evidence

ORD record
ord-bb0744f9a90348daaed9e5cfd1ddfd4b
Source dataset
uspto-grants-2011_03
Patent number
US07902201B2

Reaction notes

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