HCID 59761158, compound → HCID 178480363, compound

Participants

Reaction Conditions

Reaction Steps

Tert-butyl 3-[[3-[4-(azetidine-1-carbonyl)phenoxy]-5-[(3S)-1-methyl-2-oxo-pyrrolidin-3-yl]oxy-benzoyl]amino]pyrazole-1-carboxylate (Intermediate 14) (388 mg, 0.67 mmol) was dissolved in acetonitrile (5 mL) and heated in a microwave for 12 minutes at 150° C., the solution was concentrated under reduced pressure to afford the product (261 mg, 82%). 1H NMR δ (300 MHz, CDCl3) 2.06-2.21 (m, 1H), 2.34 (quintet, 2H), 2.49-2.63 (m, 1H), 2.92 (s, 3H), 3.31-3.52 (m, 2H), 4.15-4.38 (m, 4H), 4.87 (t, 1H), 6.77 (s, 1H), 6.80 (s, 1H), 6.98 (d, 2H), 7.17 (s, 1H), 7.38 (s, 1H), 7.48 (s, 1H), 7.61 (d, 2H), 10.29 (s, 1H); m/z 476 (M+H)+.

Provenance & Evidence