反应详情

温度

80 °C

To a mixture of 7-benzyl-3-pentyl-6-thioxo-1,3,6,7-tetrahydro-2H-purin-2-one (5.3 g, 16 mmol) in a solution of sodium hydroxide in water (2 M, 50.0 mL) was added dimethyl sulfate (2.3 mL, 24 mmol). The reaction mixture was stirred at 80° C. overnight, quenched with acetic acid and extracted with dichloromethane (DCM). The organic layer was dried and concentrated to provide the desired product (5.2 g, 98% yield). LCMS calculated for C18H23N4OS (M+H): 343.2. found: 343.1.

1. customquenched with acetic acid
2. extractionextracted with dichloromethane (DCM)
3. customThe organic layer was dried
4. concentrationconcentrated