Hydrazine → HCID 178446229, compound

HRID 600574Notes

Reaction equation

HRID 600574 reaction equation
[CH2:1]([N:8]1[C:16]2[C:15](SC)=[N:14][C:13](=[O:19])[N:12]([CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])[C:11]=2[N:10]=[CH:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:25][NH2:26]>>[CH2:1]([N:8]1[C:16]2/[C:15](=[N:25]/[NH2:26])/[NH:14][C:13](=[O:19])[N:12]([CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])[C:11]=2[N:10]=[CH:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 9321HydrazineHCID 598538237-Benzyl-6-(methylthio)-3-pentyl-3,7-dihydro-2H-purin-2-one

Product 1

HCID 178446229HCID 178446229, compoundYield 60%

Conditions

Temperature
100 °C

Procedure

7-Benzyl-6-(methylthio)-3-pentyl-3,7-dihydro-2H-purin-2-one (1.2 g, 3.5 mmol) and hydrazine (10 mL, 100 mmol) were mixed. After being stirred at 100° C. overnight, the solution was concentrated in vacuum. The residue was dissolved in DMSO and purified using preparative LCMS. The product fractions were collected and lyophilized to provide the product as a white powder (0.56 g, 60% yield). LCMS calculated for C17H23N6O (M+H): 327.2. found: 327.1.

Workup

  1. concentrationthe solution was concentrated in vacuum
  2. dissolutionThe residue was dissolved in DMSO
  3. custompurified
  4. customThe product fractions were collected

Sources & evidence

ORD record
ord-80362fcfd1114cac9cd9ec3a5cef8120
Source dataset
uspto-grants-2011_03
Patent number
US07902205B2

Reaction notes

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