HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → (S)-(4-ethyloxazol-2-yl)-2-(4-nitrophenyl)ethanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | 1-Bromo-2-butanone | HCID 13156 | — |
| Reactant | (S)-tert-butyl 1-amino-3-(4-nitrophenyl)-1-oxopropan-2-ylcarbamate | HCID 14134844 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | (S)-(4-ethyloxazol-2-yl)-2-(4-nitrophenyl)ethanamine | HCID 59464675 | — |
Reaction Steps
A mixture of [1-(S)-carbamoyl-2-(4-nitrophenyl)ethyl-carbamic acid tert-butyl ester, 1, (10 g, 32.3 mmol) and 1-bromo-2-butanone (90%, 4.1 mL, 36 mmol) in CH3CN (500 mL) is refluxed for 18 hours. The reaction mixture is cooled to room temperature and diethyl ether is added to the solution and the precipitate which forms is removed by filtration and is used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09440963B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-9a0834988b9649daa759415552dc98ce |
| Source note | uspto-grants-2016_09 |