反应详情

To a solution of methyl 3-(3-benzyl-1,2,4-oxadiazol-5-yl)propanoate (5.2 g, 21.1 mmole) in methanol (30 ml) was added 50 ml of 1N NaOH aqueous solution. The mixture was stirred at room temperature for 2 hours. After the reaction solution was adjusted to be acidic (pH=3-4) at 0° C., the reaction mixture was extracted with EtOAc 3 times. The combined organic layers were washed with water and brine, dried over Na2SO4, filtered and concentrated to give the desired product as colorless oil (4.8 g, 98%). LCMS calculated for C12H13N2O3 (M+H): 233.1. found: 233.1.

1. customat 0° C.
2. extractionthe reaction mixture was extracted with EtOAc 3 times
3. washThe combined organic layers were washed with water and brine
4. dry with materialdried over Na2SO4
5. filtrationfiltered
6. concentrationconcentrated