Hydrazinecarboxaldehyde → N-Pentyl-5-(1H-1,2,4-triazol-5-yl)-1H-imidazol-4-amine

HRID 600602Notes

Reaction equation

HRID 600602 reaction equation
[CH2:1]([NH:6][C:7]1[N:8]=[CH:9][NH:10][C:11]=1[C:12](SC)=[NH:13])[CH2:2][CH2:3][CH2:4][CH3:5].[CH:16]([NH:18][NH2:19])=O>C(O)C>[CH2:1]([NH:6][C:7]1[N:8]=[CH:9][NH:10][C:11]=1[C:12]1[NH:19][N:18]=[CH:16][N:13]=1)[CH2:2][CH2:3][CH2:4][CH3:5]

Participants

4

Reactant 2

HCID 12229HydrazinecarboxaldehydeHCID 135984704methyl 4-(pentylamino)-1H-imidazole-5-carbimidothioate

Product 1

HCID 135984707N-Pentyl-5-(1H-1,2,4-triazol-5-yl)-1H-imidazol-4-amine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of methyl 4-(pentylamino)-1H-imidazole-5-carbimidothioate (0.53 g, 2.4 mmol) and formic hydrazide (0.21 g, 3.5 mmol) in ethanol (10 mL) was refluxed overnight. The reaction mixture was concentrated under reduced pressure to yield the desired product as a slightly green viscose oil. LCMS calculated for C10H17N6 (M+H): 221.2. found: 221.1.

Workup

  1. temperaturewas refluxed overnight
  2. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-d30de258e886429881645458ed7db97c
Source dataset
uspto-grants-2011_03
Patent number
US07902205B2

Reaction notes

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