Ethylorthoformate → HCID 59853811, compound

HRID 600607Notes

Reaction equation

HRID 600607 reaction equation
[Cl:1][C:2]1[NH:3]/[C:4](=[N:17]\[NH2:18])/[C:5]2[N:6]=[CH:7][N:8]([CH:11]3[CH2:16][CH2:15][CH2:14][CH2:13][O:12]3)[C:9]=2[N:10]=1.[CH:19]([O-])([O-])OCC>>[Cl:1][C:2]1[N:3]2[CH:19]=[N:18][N:17]=[C:4]2[C:5]2[N:6]=[CH:7][N:8]([CH:11]3[CH2:16][CH2:15][CH2:14][CH2:13][O:12]3)[C:9]=2[N:10]=1

Participants

4

Reactant 3

HCID 53630039EthylorthoformateHCID 59853831HCID 59853831, compoundHCID 178514364HCID 178514364, compound

Product 1

HCID 59853811HCID 59853811, compound

Procedure

A mixture of (6Z)-2-chloro-9-(tetrahydro-2H-pyran-2-yl)-1,9-dihydro-6H-purin-6-one hydrazone [which is a tautomeric form of 2-chloro-6-hydrazino-9-(tetrahydro-2H-pyran-2-yl)-9H-purine; 0.1 g, 0.5 mmol] and ethyl orthoformate (3 g, 20 mmol) was stirred at 98° C. for 12 hours. The reaction mixture was concentrated under reduced pressure to provide the product. LCMS calculated for C11H12ClN6O (M+H): 279.1. found: 279.0.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customto provide the product

Sources & evidence

ORD record
ord-ac4e96cb1e3f47fc8582e1ee04c58199
Source dataset
uspto-grants-2011_03
Patent number
US07902205B2

Reaction notes

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