Phenyl[6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]methanone hydrobromide → Phenyl[6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]methanone

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Reaction Steps

0.32 g of phenyl[6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]methanone hydrobromide (1:1) is suspended in 10 mL of ethanol and the reaction medium is refluxed for 2 hours and then concentrated under reduced pressure. The residue is taken up in 10 mL of dichloromethane and 3 mL of aqueous normal sodium hydroxide solution. The organic phase is washed with water, dried over magnesium sulfate and concentrated to dryness under reduced pressure to give 220 mg of phenyl[6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]methanone in the form of a yellow solid.

Provenance & Evidence